Abstract: Based on GIS spatial analysis technology, the geographical information data such as tourism resources POI in Sichuan Province were takend as the research object, and the spatial distribution characteristics of various tourism resources were identified by spatial analysis methods such as kernel density algorithm, standard deviation ellipse, spatial autocorrelation, and the influencing factors of the formation of distribution patterns were explored from two major factors of nature and humanity. The results showed that: (1) The spatial agglomeration distribution characteristics of various tourism resources in Sichuan Province were obvious and showed a hierarchical trend of decreasing from the center to the surrounding areas, with an overall distribution pattern of more in the east and less in the west, mainly distributed in Chengdu City, Deyang City, and Ya'an City. (2) The spatial distribution direction of various types of tourism resources was consistent with the distribution characteristics of scenic spots. The directionality and centripetal orientation of modern humanistic tourism resources were not obvious, while the directionality and centripetal orientation of the other four types of tourism resources had varying degrees of agglomeration characteristics. (3) There were significant spatial differences in the distribution of cold and hot spots in various cities' tourism resources. The distribution of biological landscape tourism resources was relatively uniform, and the geographical landscape tourism resources were the most abundant in the hot spots within the city. The cold and hot spots of water scenery and modern cultural landscape tourism resources had similarities in regional distribution characteristics. (4) This paper analyzed the influencing factors from two aspects: natural conditions and socio-economic conditions. Among them, topography and hydrology were the internal decisive forces affecting the distribution of various tourist attraction in Sichuan Province, while socio-economic level, traffic conditions and population were the important external forces influencing the development and construction of tourist attractions.