Abstract: Study the environmental toxicity of degradable and super absorbent bamboo fiber, and provide experimental basis for its safe utilization. In this paper, SPF NIH mice were used as experimental animals to study the toxicity of super absorbent bamboo fiber to mice by intragastric administration with different concentrations of super absorbent bamboo fiber. The results showed that no mice died during the toxicity test. There were no tremors, convulsions, salivation, diarrhea, lethargy or coma in all test groups. The appetite of mice was also normal, and there were no diarrhea and anorexia. There was no obvious abnormality in all organs of all mice in the test group. When the super absorbent bamboo fiber was treated by gavage to 5000 mg/kg •bw, the mice did not die and could gain weight normally. According to the toxicity classification, super absorbent bamboo fiber was actually non-toxic.