Abstract: Ecological spatial network can strengthen the connectivity between fragmented habitat patches and landscapes, which is particularly important in the ecological protection and restoration projects of mountains, forests, fields, lakes and grass. In this paper, considering the natural and human factors, Panzhihua city was selected as the study area, and the ecological network was constructed by comprehensive application of morphological spatial pattern analysis （MSPA） and minimum cumulative resistance model （MCR）. The important ecological corridors were quantitatively evaluated by gravity model, and the optimization countermeasures were put forward. The results showed that the ecological network of Panzhihua city was composed of 10 ecological sources and 28 effective potential ecological corridors. Combined with gravity model, 7 first-class ecological corridors, 10 second-class ecological corridors and 11 general ecological corridors were extracted. The spatial distribution of the core density of the ecological corridor was unevenly distributed, mainly distributed in the northwest, and the ecological mobility was weak as a whole. The ecological network was optimized by adding ecological sources, identifying ecological nodes and ecological breakpoints, and the countermeasures of ecological spatial network framework layout were put forward. The research can provide scientific references for the sustainable development of ecological environment in Panzhihua city.