Abstract: From April 2008 to December 2021, 84 camera monitoring sites were set up in and around Sichuan Yele Nature Reserve to monitor large and medium-sized mammals and ground birds, with a total of 4504 effective camera working days, and a total of 2039 independent and effective records were obtained. 19 species of wild mammals belonging to 15 families, 4 orders, and 19 species of wild birds belonging to 8 families and 3 orders were identified, including 4 species of national class I and 17 species of national class II key protected wild animals. Based on the relative abundance index and site occupancy, Tufted Deer （Elaphodus cephalophus） （RAI=16.408; SO=65.48%）, Chinses Serow （Capricornis milneedwardsii） （RAI=11.878; SO=30.95%）, Northern Hog Badger （Arctonyx collaris） （RAI=1.465; SO=27.38%）, Wild Boar （Sus scrofa） （RAI=1.332; SO=21.43%） and Red Panda （Ailurus fulgens） （RAI=0.977; SO=26.19%） were ranked as the 5 most abundant mammal species, and Blood Pheasant （Ithaginis cruentus） （RAI=5.662; SO=34.52%）, Temminck’s Tragopan （Tragopan temminckii） （RAI=3.730; SO=22.62%）, Giant Laughingthrush （Garrulax maximus） （RAI=0.222; SO=7.14%）, Elliot’s Laughingthrush （Trochalopteron elliotii） （RAI=0.133; SO=4.76%） and Chestnut Thrush （Turdus rubrocanus） （RAI=0.133; SO=5.95%） were ranked as the 5 most abundant bird species. Meanwhile, one mammal species namely Grey-headed Flying Squirrel （Petaurista caniceps） and nine bird species including Koklass Pheasant （Pucrasia macrolopha）, Bearded Vulture （Gypaetus barbatus）, White-browed Bush Robin （Tarsiger indicus）, White’s Thrush （Zoothera aurea）, Plain-backed Thrush （Zoothera mollissima）, Long-tailed Thrush （Zoothera dixoni）, Spotted Laughingthrush （Garrulax ocellatus）, Maroon-backed Accentor （Prunella immaculata）, White-winged Grosbeak （Mycerobas carnipes）, were new records in the nature reserve. The results of activity rhythm analysis showed that the Tufted Deer, Blood Pheasant and Temminck’s Tragopan were diurnal animals, while Chinses Serow had no obvious diurnal activity. This study preliminarily grasped the current information of species composition, relative abundance and population distribution of large and medium-sized mammals and ground birds in Yele Nature Reserve, which could provide important basic information for more detailed species conservation and management in the nature reserve.