Abstract: In order to explore the suitable growing areas of Z. bungeanum and Z. armatum and scientifically select cultivation areas, 196 samples of Z. bungeanum and 289 samples of Z. armatum were collected, and the ecological suitability analysis was conducted by using GMPGIS (Geographic Information System for Global Medicinal Plants, GMPGIS). The results showed that 28 provinces in China including Yunnan, Sichuan, Hubei, Shanxi, Hunan and Guizhou were ecologically suitable for Z. bungeanum, while 21 provinces including Yunnan, Sichuan, Guangxi, Hunan, Hubei and Guizhou were ecologically suitable for Z. armatum. There are 55 countries and regions in the world suitable for growing Z. bungeanum, mainly in Asia, Europe and North America. 42 countries and regions in the world were suitable for the growth of Z. armatum, mainly in Asia, Europe, North America, South America and Oceania. Both China and the United States had the largest area, accounting for more than 70% of the total area of the global suitable area. There were obvious differences in the distribution of Z. bungeanum and Z. armatum. The suitable area of Z. bungeanum was wider than that of Z. armatum, and there was a certain overlapping area in the distribution of Z. bungeanum and Z. armatum.