Abstract: Zoige Nature Reserve in Sichuan province is not only an important water resource conservation area, but also one of the key biodiversity areas in China. Dynamic analysis of landscape ecological pattern in this area is beneficial for scientific protection and utilization of wetland resources in Zoige Plateau. In this paper, Landsat5 TM images in 2004 and 2009 and Landsat8 OLI remote sensing data in 2014, 2016 were selected, and the landscape of the study area was divided into lakes, swamps, high-coverage meadows, low-coverage meadows, swamped meadows and desertification by using supervised classification method after the preprocessing of registration, fusion and cropping of images in different phases in ENVI5.5 software platform. At last, eight major landscape indexes were selected using Fragstats4.2 software, and the landscape pattern of Zoige Nature Reserve was compared and analyzed at patch types and landscape levels. The results showed that: (1) From 2004 to 2016, the landscape such as swamps and swamped meadows shifted to low-coverage and high-coverage meadows; (2) From 2004 to 2016, the swamp area gradually decreased. After 2009, the swamp area tended to be stable and the decreasing rate slowed down; (3) In a word, the basic landscape ecological pattern of Zoige Nature Reserve has slight change, and the meadow is the most dominant landscape type in the study area.