Abstract: Field surveys in Zhanjiang Mangrove National Nature Reserve were conducted respectively in April and October, 2017. Snap traps (1 330 traps per day) were used to capture small mammals, and the line transect method (60 transects) and interviews with local people were used to survey amphibians and reptiles. Combined with data in available references, there were 18 species of amphibians belonging to 1 order, 7 families and 13 genera; 13 species of reptiles belonging to 1 order, 6 families and 11 genera;21 species of mammals belonging to 4 orders, 7 families and 14 genera recognized in Zhanjiang Mangrove National Nature Reserve. Two species was listed in Chinese National Key Protected Wild Animals and 1 species of reptile was endemic to China. Analyses of composition of the fauna indicated that all amphibians, reptiles and 14 species of mammals belonged to Oriental realm. The management and reservation measures were proposed to protect the abundant amphibian, reptilian and mammalian resources in Zhanjiang Mangrove National Nature Reserve.