Abstract: The alpine pika(Ochotona curzoniae) is a serious plague of rats occurring in recent years in the territory of Ruoergai county, mainly eating the forage, destucting grassland ecosystem, causing soil erosion, resulting in serious consequences of grassland stocking rate decrease and grassland desertification,and also spreading diseases harmful to human health. For this reason,tests were made to use the biological control technology for controlling rodents.The results showed that the medicine named Shishuangshuba had an obvions effect in the prevention of Ochotona curzoniae,reaching the effective decreasing the hole rate of 93%, and poisoned non-target animals or animal predators phenomenon were not found.Pharmacy palatability test was up to 90% in one day.