Abstract: A pot experiment was conducted to study the physiological responses of Pilea cadierei Gagnep. et Guill to single cadmium(Cd) or lead(Pb), and their combined treatment. The results showed that the activities of SOD in leaves would increase with the concentration increasing of single Cd and Pb. When P. cadierei was treated with combined Cd and Pb, the activities of SOD would decrease. The activities of POD increased in the use of lower Pb concentration but decreased in the use of higher Pb concentration. It was indicated that Pilea cadierei had definite Pb-tolerance capability in the use of lower Pb concentration but was damaged in the use of higher Pb concentration. In the use of combined treatments of Cd and Pb, the activities of POD would gradually decrease. That further confirmed that the combined treatment had a higher toxcicity than single Cd or Pb treatment. The contents of Pro and MDA all would gradually increase with the concentration increasing of single or combined Cd and Pb, which was a physiological adaptation of plants to heavy metal stress.