Abstract: Based on the desertification monitoring data and soil data of Zoige county in 2009 and 2014, and with the support of GIS technology, the distribution and dynamic changes of desertification in Zoige county were quantitatively analyzed, which provided scientific basis for the countermeasures of desertification control and ecological environment construction. In addition based on GIS, the study area was divided into desertification prevention and control zones, which provided more intuitive and accurate judgment and decision-making means for desertification control. The main results were as follows: (1) The distribution of desertification patches was aggregated and the spatial heterogeneity was obvious; (2) The clustering of monitoring patches with high desertification degree was obvious, which indicated that the patches with high desertification degree were aggregated in space; (3) The desertification trend was expanding to the northwest, especially to the Yellow River and Heihe River. Within 6 km of the river channel, about 70% of the land with obvious desertification trend and 60% of the desertified land were included; (4) The desertification land in the two stages of was mainly light sandy land, which indicated that land desertification in Zoige county was still in the initial stage, which was a favorable period for desertification control; (5) The research area was divided into key control areas, general control areas, general protection areas and potential protection areas. Finally, the control strategies were put forward