Abstract: In order to investigate the short-term control effects of different biological rodenticides on plateau pika (Ochotona curzoniae), a comparative experiment was conducted in Zoige county in May 2022 on the feeding rate and control effects of four biological rodenticides, named Xinbeiao (BR1), Bromadiolone (BR2), Stratagemò (BR3) and Shudaonan (BR4), respectively, in order to provide basic data for the selection of rodent population control rodenticides in degraded grassland on plateau. The results showed that: (1) The short-term feeding rate of plateau pika on the four chemicals was as follows: BR4 (100.0 %)> BR3 (98.3 %) > BR1 (77.0 %) > BR2 (67.4 %). (2) The rate of killing holes with chemicals was BR2 (86.0 %) > BR4 (52.9 %) > BR1 (41.0 %) > BR3 (34.8 %). BR2 had the best short-term control effect, followed by BR4 and BR1. Considering ecological security, grassland degradation degree, rodent population status, palatability, mechanism of action and control effect, BR2 and BR4 could be used for emergency control of plateau pika population in severely degraded grassland. But the protection of non-target mammals should be strengthened when applying BR2. For the long-term routine prevention and control of moderately and lightly degraded grassland, BR1 and BR3 could be used.