Abstract: In this paper, by observing and studying the diseases and insect pests of walnut in different regions of Wuxi County for 3 years, the main diseases and insect pests affecting the yield of walnut in Wuxi were mainly walnut giant elephant, cloudy blotch, black spot and brown spot, and it was summed up as "two insects and two diseases". According to the incidence regularity of two pests and two diseases at different altitudes and pest control experiments in Wuxi, the prevention and control methods at different altitudes in Wuxi were preliminarily summarized.